HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is crucial for the development of adult T-cell leukemia (ATL), a highly malignant CD4(+) T cell neoplasm. Among the multiple aberrant Tax-induced effects on cellular processes, persistent activation of transcription factor NF-κB, which i...

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Detalles Bibliográficos
Autores principales: Shibata, Yuri, Tokunaga, Fuminori, Goto, Eiji, Komatsu, Ginga, Gohda, Jin, Saeki, Yasushi, Tanaka, Keiji, Takahashi, Hirotaka, Sawasaki, Tatsuya, Inoue, Satoshi, Oshiumi, Hiroyuki, Seya, Tsukasa, Nakano, Hiroyasu, Tanaka, Yuetsu, Iwai, Kazuhiro, Inoue, Jun-ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283754/
https://www.ncbi.nlm.nih.gov/pubmed/28103322
http://dx.doi.org/10.1371/journal.ppat.1006162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283754/
https://www.ncbi.nlm.nih.gov/pubmed/28103322
http://dx.doi.org/10.1371/journal.ppat.1006162

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