KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype

Netherton syndrome (NS) is a severe skin disease caused by the loss of protease inhibitor LEKTI, which leads to the dysregulation of epidermal proteases and severe skin-barrier defects. KLK5 was proposed as a major protease in NS pathology, however its inactivation is not sufficient to rescue the le...

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Detalles Bibliográficos
Autores principales: Kasparek, Petr, Ileninova, Zuzana, Zbodakova, Olga, Kanchev, Ivan, Benada, Oldrich, Chalupsky, Karel, Brattsand, Maria, Beck, Inken M., Sedlacek, Radislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283769/
https://www.ncbi.nlm.nih.gov/pubmed/28095415
http://dx.doi.org/10.1371/journal.pgen.1006566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283769/
https://www.ncbi.nlm.nih.gov/pubmed/28095415
http://dx.doi.org/10.1371/journal.pgen.1006566

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