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Dynamics of BAF- Polycomb Complex Opposition on Heterochromatin in Normal and Oncogenic States

The opposition between polycomb repressive complexes (PRC) and BAF (mSWI/SNF) complexes plays critical roles in development and disease. Mutations in the genes encoding BAF subunits contribute to over 20% of human malignancy, yet the underlying mechanisms remain unclear owing largely to a lack of as...

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Detalles Bibliográficos
Autores principales: Kadoch, Cigall, Williams, Robert T., Calarco, Joseph P., Miller, Erik L., Weber, Christopher M., Braun, Simon G., Pulice, John L., Chory, Emma J., Crabtree, Gerald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285326/
https://www.ncbi.nlm.nih.gov/pubmed/27941796
http://dx.doi.org/10.1038/ng.3734