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Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides

To get a better insight into the antimicrobial potency of short cationic lipopeptides, 35 new entities were synthesized using solid phase peptide strategy. All newly obtained lipopeptides were designed to be positively charged from +1 to +4. This was achieved by introducing basic amino acid - lysine...

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Detalles Bibliográficos
Autores principales: Greber, Katarzyna E., Dawgul, Malgorzata, Kamysz, Wojciech, Sawicki, Wieslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285354/
https://www.ncbi.nlm.nih.gov/pubmed/28203232
http://dx.doi.org/10.3389/fmicb.2017.00123