Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

DNA:RNA hybrids, nucleic acid structures with diverse physiological functions, can disrupt genome integrity when dysregulated. Human telomeres were shown to form hybrids with the lncRNA TERRA, yet the formation and distribution of these hybrids among telomeres, their regulation and their cellular ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Sagie, Shira, Toubiana, Shir, Hartono, Stella R., Katzir, Hagar, Tzur-Gilat, Aya, Havazelet, Shany, Francastel, Claire, Velasco, Guillaume, Chédin, Frédéric, Selig, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286223/
https://www.ncbi.nlm.nih.gov/pubmed/28117327
http://dx.doi.org/10.1038/ncomms14015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286223/
https://www.ncbi.nlm.nih.gov/pubmed/28117327
http://dx.doi.org/10.1038/ncomms14015

Ejemplares similares