Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid

Patients taking antidepressants, including Clomipramine (CLP), have an increased risk of osteoporotic fracture. However, the effects of CLP on bone metabolism are unknown. Here, we demonstrate that WT mice treated with CLP for 2 weeks had significantly reduced trabecular bone volume and cortical bon...

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Detalles Bibliográficos
Autores principales: Li, Xing, Sun, Wen, Li, Jinbo, Wang, Mengmeng, Zhang, Hengwei, Pei, Lingpeng, Boyce, Brendan F., Wang, Zhiyu, Xing, Lianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286409/
https://www.ncbi.nlm.nih.gov/pubmed/28145497
http://dx.doi.org/10.1038/srep41358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286409/
https://www.ncbi.nlm.nih.gov/pubmed/28145497
http://dx.doi.org/10.1038/srep41358

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