Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

GRP78, a multifunctional protein with potent cytoprotective properties, is an emerging therapeutic target to combat cancer development, progression and drug resistance. The biological consequences of prolonged reduction in expression of this essential chaperone which so far has been studied primaril...

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Detalles Bibliográficos
Autores principales: Lee, Amy S., Brandhorst, Sebastian, Rangel, Daisy F., Navarrete, Gerardo, Cohen, Pinchas, Longo, Valter D., Chen, Jeannie, Groshen, Susan, Morgan, Todd E., Dubeau, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286507/
https://www.ncbi.nlm.nih.gov/pubmed/28145503
http://dx.doi.org/10.1038/srep40919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286507/
https://www.ncbi.nlm.nih.gov/pubmed/28145503
http://dx.doi.org/10.1038/srep40919

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