Cargando…

The PIDDosome activates p53 in response to supernumerary centrosomes

Centrosomes, the main microtubule-organizing centers in animal cells, are replicated exactly once during the cell division cycle to form the poles of the mitotic spindle. Supernumerary centrosomes can lead to aberrant cell division and have been causally linked to chromosomal instability and cancer....

Descripción completa

Detalles Bibliográficos
Autores principales:	Fava, Luca L., Schuler, Fabian, Sladky, Valentina, Haschka, Manuel D., Soratroi, Claudia, Eiterer, Lisa, Demetz, Egon, Weiss, Guenter, Geley, Stephan, Nigg, Erich A., Villunger, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287111/ https://www.ncbi.nlm.nih.gov/pubmed/28130345 http://dx.doi.org/10.1101/gad.289728.116

Ejemplares similares

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome
por: Manzl, C, et al.
Publicado: (2013)

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation
por: Sladky, Valentina C., et al.
Publicado: (2020)

Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26
por: Burigotto, Matteo, et al.
Publicado: (2020)

PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis
por: Sladky, Valentina C, et al.
Publicado: (2020)

The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest
por: Haschka, Manuel D., et al.
Publicado: (2015)

PIDDosome-independent tumor suppression by Caspase-2
por: Manzl, C, et al.
Publicado: (2012)

Caspase-2 activation in the absence of PIDDosome formation
por: Manzl, Claudia, et al.
Publicado: (2009)

Centrosome Aberrations Associated with Cellular Senescence and p53 Localization at Supernumerary Centrosomes
por: Ohshima, Susumu
Publicado: (2012)

Iron at the interface of immunity and infection
por: Nairz, Manfred, et al.
Publicado: (2014)

PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs
por: Heikaus, Sebastian, et al.
Publicado: (2010)

BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis
por: Grespi, Francesca, et al.
Publicado: (2010)

Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes
por: Navarro-Serer, Bernat, et al.
Publicado: (2019)

MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment
por: Haschka, Manuel D., et al.
Publicado: (2020)

Embryonic stem cell differentiation requires full length Chd1
por: Piatti, Paolo, et al.
Publicado: (2015)

IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis
por: Vitre, Benjamin, et al.
Publicado: (2020)

KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells
por: Mashima, Yu, et al.
Publicado: (2022)

The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion
por: Mayor, Thibault, et al.
Publicado: (2000)

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus
por: Ando, Kiyohiro, et al.
Publicado: (2017)

The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents
por: Karbon, Gerlinde, et al.
Publicado: (2021)

Perturbing mitosis for anti‐cancer therapy: is cell death the only answer?
por: Haschka, Manuel, et al.
Publicado: (2018)

PIDD mediates and stabilizes the interaction between RAIDD and Caspase-2 for the PIDDosome assembly
por: Jang, Tae-ho, et al.
Publicado: (2013)

Structural centrosome aberrations sensitize polarized epithelia to basal cell extrusion
por: Ganier, Olivier, et al.
Publicado: (2018)

Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance
por: Garcia‐Carpio, Irmina, et al.
Publicado: (2023)

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway
por: Contadini, Claudia, et al.
Publicado: (2019)

DMT1 Protects Macrophages from Salmonella Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression
por: Grander, Manuel, et al.
Publicado: (2022)

Flexible Stoichiometry and Asymmetry of the PIDDosome Core Complex by Heteronuclear NMR Spectroscopy and Mass Spectrometry
por: Nematollahi, Lily A., et al.
Publicado: (2015)

Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging
por: Bauer, Manuel, et al.
Publicado: (2016)

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity
por: Thein, Kerstin H., et al.
Publicado: (2007)

Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
por: Schuler, Fabian, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes
por: Watts, Ciorsdaidh A., et al.
Publicado: (2013)

Rootletin forms centriole-associated filaments and functions in centrosome cohesion
por: Bahe, Susanne, et al.
Publicado: (2005)

p53 censuses centrosomes
por: Leslie, Mitch
Publicado: (2015)

Structural centrosome aberrations promote non‐cell‐autonomous invasiveness
por: Ganier, Olivier, et al.
Publicado: (2018)

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes
por: Sonnen, Katharina F., et al.
Publicado: (2012)

The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review
por: Pizzini, Alex, et al.
Publicado: (2017)

Generation and Evaluation of an IPTG-Regulated Version of Vav-Gene Promoter for Mouse Transgenesis
por: Grespi, Francesca, et al.
Publicado: (2011)

Genetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium Infection
por: Nairz, Manfred, et al.
Publicado: (2017)

Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication
por: Yu, Zhixian, et al.
Publicado: (2016)

The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death
por: Bock, Florian J., et al.
Publicado: (2015)

Ferritin H deficiency deteriorates cellular iron handling and worsens Salmonella typhimurium infection by triggering hyperinflammation
por: Haschka, David, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i11krqsemdavneffdv9qdt9ocb