APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context

APOBEC3A/B cytidine deaminase is responsible for the majority of cancerous mutations in a large fraction of cancer samples. However, its role in heritable mutagenesis remains very poorly understood. Recent studies have demonstrated that both in yeast and in human cancerous cells, most APOBEC3A/B-ind...

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Detalles Bibliográficos
Autores principales: Seplyarskiy, Vladimir B., Andrianova, Maria A., Bazykin, Georgii A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287224/
https://www.ncbi.nlm.nih.gov/pubmed/27940951
http://dx.doi.org/10.1101/gr.210336.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287224/
https://www.ncbi.nlm.nih.gov/pubmed/27940951
http://dx.doi.org/10.1101/gr.210336.116

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