Using reference-free compressed data structures to analyze sequencing reads from thousands of human genomes

We are rapidly approaching the point where we have sequenced millions of human genomes. There is a pressing need for new data structures to store raw sequencing data and efficient algorithms for population scale analysis. Current reference-based data formats do not fully exploit the redundancy in po...

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Detalles Bibliográficos
Autores principales: Dolle, Dirk D., Liu, Zhicheng, Cotten, Matthew, Simpson, Jared T., Iqbal, Zamin, Durbin, Richard, McCarthy, Shane A., Keane, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287235/
https://www.ncbi.nlm.nih.gov/pubmed/27986821
http://dx.doi.org/10.1101/gr.211748.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287235/
https://www.ncbi.nlm.nih.gov/pubmed/27986821
http://dx.doi.org/10.1101/gr.211748.116

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