Characterization of ADME gene variation in 21 populations by exome sequencing

OBJECTIVE: Proteins involving absorption, distribution, metabolism, and excretion (ADME) play a critical role in drug pharmacokinetics. The type and frequency of genetic variation in the ADME genes differ among populations. The aim of this study was to systematically investigate common and rare ADME...

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Detalles Bibliográficos
Autores principales: Hovelson, Daniel H., Xue, Zhengyu, Zawistowski, Matthew, Ehm, Margaret G., Harris, Elizabeth C., Stocker, Sophie L., Gross, Annette S., Jang, In-Jin, Ieiri, Ichiro, Lee, Jong-Eun, Cardon, Lon R., Chissoe, Stephanie L., Abecasis, Gonçalo, Nelson, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287433/
https://www.ncbi.nlm.nih.gov/pubmed/27984508
http://dx.doi.org/10.1097/FPC.0000000000000260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287433/
https://www.ncbi.nlm.nih.gov/pubmed/27984508
http://dx.doi.org/10.1097/FPC.0000000000000260

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