Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer

FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins for ubiquitination and degradation by the proteasome. FBXW7 regulates cellular apoptosis by targeting MCL1 for ubiquitination. Recently, we identified PLK1 as a new substrat...

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Detalles Bibliográficos
Autores principales: Gasca, Jessica, Flores, Maria Luz, Giráldez, Servando, Ruiz-Borrego, Manuel, Tortolero, María, Romero, Francisco, Japón, Miguel A., Sáez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288146/
https://www.ncbi.nlm.nih.gov/pubmed/27409838
http://dx.doi.org/10.18632/oncotarget.10481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288146/
https://www.ncbi.nlm.nih.gov/pubmed/27409838
http://dx.doi.org/10.18632/oncotarget.10481

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