TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation

The mechanism of telomerase re-activation in cancer had remained elusive until the discovery of frequent mutations in the promoter of the TERT gene that encodes the catalytic reverse transcriptase subunit of telomerase. We investigated the regulation of TERT expression in melanoma cell lines and our...

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Detalles Bibliográficos
Autores principales: Vallarelli, Andrelou F., Rachakonda, P. Sivaramakrishna, André, Jocelyne, Heidenreich, Barbara, Riffaud, Laurence, Bensussan, Armand, Kumar, Rajiv, Dumaz, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288173/
https://www.ncbi.nlm.nih.gov/pubmed/27449293
http://dx.doi.org/10.18632/oncotarget.10634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288173/
https://www.ncbi.nlm.nih.gov/pubmed/27449293
http://dx.doi.org/10.18632/oncotarget.10634

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