Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer

Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in f...

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Autores principales: Kim, Rae-Kwon, Kaushik, Neha, Suh, Yongjoon, Yoo, Ki-Chun, Cui, Yan-Hong, Kim, Min-Jung, Lee, Hae-June, Kim, In-Gyu, Lee, Su-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288197/
https://www.ncbi.nlm.nih.gov/pubmed/27462787
http://dx.doi.org/10.18632/oncotarget.10802
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author Kim, Rae-Kwon
Kaushik, Neha
Suh, Yongjoon
Yoo, Ki-Chun
Cui, Yan-Hong
Kim, Min-Jung
Lee, Hae-June
Kim, In-Gyu
Lee, Su-Jae
author_facet Kim, Rae-Kwon
Kaushik, Neha
Suh, Yongjoon
Yoo, Ki-Chun
Cui, Yan-Hong
Kim, Min-Jung
Lee, Hae-June
Kim, In-Gyu
Lee, Su-Jae
author_sort Kim, Rae-Kwon
collection PubMed
description Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JAK/STAT3 signaling axis in mammary tumor cells. Collectively, we present converging evidence from our studies that Notch2 is a critical mediator of radiation-induced EMT and responsible for induced malignant tumor growth.
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spelling pubmed-52881972017-02-07 Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer Kim, Rae-Kwon Kaushik, Neha Suh, Yongjoon Yoo, Ki-Chun Cui, Yan-Hong Kim, Min-Jung Lee, Hae-June Kim, In-Gyu Lee, Su-Jae Oncotarget Research Paper Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JAK/STAT3 signaling axis in mammary tumor cells. Collectively, we present converging evidence from our studies that Notch2 is a critical mediator of radiation-induced EMT and responsible for induced malignant tumor growth. Impact Journals LLC 2016-07-23 /pmc/articles/PMC5288197/ /pubmed/27462787 http://dx.doi.org/10.18632/oncotarget.10802 Text en Copyright: © 2016 Kim et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Kim, Rae-Kwon
Kaushik, Neha
Suh, Yongjoon
Yoo, Ki-Chun
Cui, Yan-Hong
Kim, Min-Jung
Lee, Hae-June
Kim, In-Gyu
Lee, Su-Jae
Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
title Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
title_full Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
title_fullStr Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
title_full_unstemmed Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
title_short Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
title_sort radiation driven epithelial-mesenchymal transition is mediated by notch signaling in breast cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288197/
https://www.ncbi.nlm.nih.gov/pubmed/27462787
http://dx.doi.org/10.18632/oncotarget.10802
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