The mutational profile and infiltration pattern of murine MLH1(-/-) tumors: concurrences, disparities and cell line establishment for functional analysis

Mice lines homozygous negative for one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6) were generated as models for MMR deficient (MMR-D) diseases. Clinically, hereditary forms of MMR-D include Lynch syndrome (characterized by a germline MMR gene defect) and constitutional MMR-D...

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Detalles Bibliográficos
Autores principales: Maletzki, Claudia, Beyrich, Franziska, Hühns, Maja, Klar, Ernst, Linnebacher, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288207/
https://www.ncbi.nlm.nih.gov/pubmed/27447752
http://dx.doi.org/10.18632/oncotarget.10677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288207/
https://www.ncbi.nlm.nih.gov/pubmed/27447752
http://dx.doi.org/10.18632/oncotarget.10677

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