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miR-28 modulates exhaustive differentiation of T cells through silencing programmed cell death-1 and regulating cytokine secretion
T cell exhaustion is a state of T cell dysfunction that arises during many cancer. miRNAs are one of major gene regulators which result in translational inhibition and/or mRNA degradation. We hypothesized that miRNAs exist that can silence PD1 and act as a modulator in vitro to revert exhaustive sta...
Autores principales: | Li, Qing, Johnston, Nathan, Zheng, Xiufen, Wang, Hongmei, Zhang, Xusheng, Gao, Dian, Min, Weiping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288217/ https://www.ncbi.nlm.nih.gov/pubmed/27447564 http://dx.doi.org/10.18632/oncotarget.10731 |
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