PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence

Alternative pathways of metabolism endowed cancer cells with metabolic stress. Inhibiting the related compensatory pathways might achieve synergistic anticancer results. This study demonstrated that pyruvate dehydrogenase E1α gene knockout (PDHA1 KO) resulted in alterations in tumor cell metabolism...

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Detalles Bibliográficos
Autores principales: Li, Yaqing, Li, Xiaoran, Li, Xiaoli, Zhong, Yali, Ji, Yasai, Yu, Dandan, Zhang, Mingzhi, Wen, Jian-Guo, Zhang, Hongquan, Goscinski, Mariusz Adam, Nesland, Jahn M., Suo, Zhenhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288225/
https://www.ncbi.nlm.nih.gov/pubmed/27462778
http://dx.doi.org/10.18632/oncotarget.10782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288225/
https://www.ncbi.nlm.nih.gov/pubmed/27462778
http://dx.doi.org/10.18632/oncotarget.10782

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