DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer

Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, wi...

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Detalles Bibliográficos
Autores principales: Mamlouk, Soulafa, Childs, Liam Harold, Aust, Daniela, Heim, Daniel, Melching, Friederike, Oliveira, Cristiano, Wolf, Thomas, Durek, Pawel, Schumacher, Dirk, Bläker, Hendrik, von Winterfeld, Moritz, Gastl, Bastian, Möhr, Kerstin, Menne, Andrea, Zeugner, Silke, Redmer, Torben, Lenze, Dido, Tierling, Sascha, Möbs, Markus, Weichert, Wilko, Folprecht, Gunnar, Blanc, Eric, Beule, Dieter, Schäfer, Reinhold, Morkel, Markus, Klauschen, Frederick, Leser, Ulf, Sers, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288500/
https://www.ncbi.nlm.nih.gov/pubmed/28120820
http://dx.doi.org/10.1038/ncomms14093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288500/
https://www.ncbi.nlm.nih.gov/pubmed/28120820
http://dx.doi.org/10.1038/ncomms14093

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