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Dietary Antioxidant Capacity and Its Association with Preeclampsia

Preeclampsia (PE) is one of the major disorders in pregnancy leading to many adverse maternal outcomes. Although the etiology of PE is not fully understood, resent studies suggest that an imbalance between free radicals production and the antioxidant defense system might have key role. Our aim of th...

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Autores principales: Sheikhi, Mahdiyeh, Sharifi-Zahabi, Elham, Paknahad, Zamzam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Clinical Nutrition 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288552/
https://www.ncbi.nlm.nih.gov/pubmed/28168181
http://dx.doi.org/10.7762/cnr.2017.6.1.47
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author Sheikhi, Mahdiyeh
Sharifi-Zahabi, Elham
Paknahad, Zamzam
author_facet Sheikhi, Mahdiyeh
Sharifi-Zahabi, Elham
Paknahad, Zamzam
author_sort Sheikhi, Mahdiyeh
collection PubMed
description Preeclampsia (PE) is one of the major disorders in pregnancy leading to many adverse maternal outcomes. Although the etiology of PE is not fully understood, resent studies suggest that an imbalance between free radicals production and the antioxidant defense system might have key role. Our aim of the current study was to evaluate the association between dietary total antioxidant capacity (TAC), serum TAC and risk of PE in women with preeclampsia and normal pregnancy. This case-control study conducted on 55 women with preeclampsia and 93 with normal pregnancy. Dietary intakes were obtained by a semi-quantitative food frequency questionnaire (FFQ) with 168 itmes. Dietary TAC was assessed according to United States Department of Agriculture (USDA) Database for oxygen radical absorbance capacity (ORAC), Release 2. Serum TAC was measured by a double-antibody sandwich enzyme-linked immunesorbent assay (ELISA). After adjusting for energy, pre-pregnant body mass index (BMI) and history of PE, no relationship was found between intake of hydrophilic-ORAC (H-ORAC), lipophilic-ORAC (L-ORAC), total phenolics (TP), total-ORAC (T-ORAC), and PE risk. However, serum TAC had a significant positive relationship with the risk of PE after adjusting for energy (odds ratio [OR], 0.07; 95% confidence interval [CI], 0.16–0.35), BMI and history of PE (OR, 0.04; 95% CI, 0.01–0.32). Findings of this study indicate that serum TAC is positively associated with the risk of PE but no association was found between intake of antioxidant indices and PE risk.
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spelling pubmed-52885522017-02-06 Dietary Antioxidant Capacity and Its Association with Preeclampsia Sheikhi, Mahdiyeh Sharifi-Zahabi, Elham Paknahad, Zamzam Clin Nutr Res Original Article Preeclampsia (PE) is one of the major disorders in pregnancy leading to many adverse maternal outcomes. Although the etiology of PE is not fully understood, resent studies suggest that an imbalance between free radicals production and the antioxidant defense system might have key role. Our aim of the current study was to evaluate the association between dietary total antioxidant capacity (TAC), serum TAC and risk of PE in women with preeclampsia and normal pregnancy. This case-control study conducted on 55 women with preeclampsia and 93 with normal pregnancy. Dietary intakes were obtained by a semi-quantitative food frequency questionnaire (FFQ) with 168 itmes. Dietary TAC was assessed according to United States Department of Agriculture (USDA) Database for oxygen radical absorbance capacity (ORAC), Release 2. Serum TAC was measured by a double-antibody sandwich enzyme-linked immunesorbent assay (ELISA). After adjusting for energy, pre-pregnant body mass index (BMI) and history of PE, no relationship was found between intake of hydrophilic-ORAC (H-ORAC), lipophilic-ORAC (L-ORAC), total phenolics (TP), total-ORAC (T-ORAC), and PE risk. However, serum TAC had a significant positive relationship with the risk of PE after adjusting for energy (odds ratio [OR], 0.07; 95% confidence interval [CI], 0.16–0.35), BMI and history of PE (OR, 0.04; 95% CI, 0.01–0.32). Findings of this study indicate that serum TAC is positively associated with the risk of PE but no association was found between intake of antioxidant indices and PE risk. Korean Society of Clinical Nutrition 2017-01 2017-01-31 /pmc/articles/PMC5288552/ /pubmed/28168181 http://dx.doi.org/10.7762/cnr.2017.6.1.47 Text en Copyright © 2017. The Korean Society of Clinical Nutrition http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sheikhi, Mahdiyeh
Sharifi-Zahabi, Elham
Paknahad, Zamzam
Dietary Antioxidant Capacity and Its Association with Preeclampsia
title Dietary Antioxidant Capacity and Its Association with Preeclampsia
title_full Dietary Antioxidant Capacity and Its Association with Preeclampsia
title_fullStr Dietary Antioxidant Capacity and Its Association with Preeclampsia
title_full_unstemmed Dietary Antioxidant Capacity and Its Association with Preeclampsia
title_short Dietary Antioxidant Capacity and Its Association with Preeclampsia
title_sort dietary antioxidant capacity and its association with preeclampsia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288552/
https://www.ncbi.nlm.nih.gov/pubmed/28168181
http://dx.doi.org/10.7762/cnr.2017.6.1.47
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