Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis

Interleukin-1β (IL-1β) is a highly inflammatory cytokine that significantly contributes to both acute and chronic inflammatory diseases. The secretion of IL-1β requires a unique protease, caspase-1, which is activated by various protein platforms called inflammasomes. Data suggests a key role for mi...

Descripción completa

Detalles Bibliográficos
Autores principales: Domiciano, Talita P., Wakita, Daiko, Jones, Heather D., Crother, Timothy R., Verri, Waldiceu A., Arditi, Moshe, Shimada, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288648/
https://www.ncbi.nlm.nih.gov/pubmed/28148962
http://dx.doi.org/10.1038/srep41539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288648/
https://www.ncbi.nlm.nih.gov/pubmed/28148962
http://dx.doi.org/10.1038/srep41539

Ejemplares similares