Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria

Endoplasmic reticulum (ER) stress is implicated in chronic kidney disease (CKD) development in patients and in animal models. Here we show that ER stress inhibition through 4-phenylbutyric acid (4-PBA) administration decreases blood pressure, albuminuria, and tubular casts in an angiotensin II/deoxy...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohammed-Ali, Zahraa, Lu, Chao, Marway, Mandeep K., Carlisle, Rachel E., Ask, Kjetil, Lukic, Dusan, Krepinsky, Joan C., Dickhout, Jeffrey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288651/
https://www.ncbi.nlm.nih.gov/pubmed/28148966
http://dx.doi.org/10.1038/srep41572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288651/
https://www.ncbi.nlm.nih.gov/pubmed/28148966
http://dx.doi.org/10.1038/srep41572

Ejemplares similares