The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1

Cardiac homeostasis requires proper control of protein turnover. Protein degradation is principally controlled by the Ubiquitin-Proteasome System. Mule is an E3 ubiquitin ligase that regulates cellular growth, DNA repair and apoptosis to maintain normal tissue architecture. However, Mule’s function...

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Detalles Bibliográficos
Autores principales: Dadson, Keith, Hauck, Ludger, Hao, Zhenyue, Grothe, Daniela, Rao, Vivek, Mak, Tak W., Billia, Filio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288653/
https://www.ncbi.nlm.nih.gov/pubmed/28148912
http://dx.doi.org/10.1038/srep41490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288653/
https://www.ncbi.nlm.nih.gov/pubmed/28148912
http://dx.doi.org/10.1038/srep41490

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