An Engineered Herpesvirus Activates Dendritic Cells and Induces Protective Immunity

Herpes simplex viruses (HSV) are human pathogens that switch between lytic and latent infection. While attenuated HSV is explored for vaccine, the underlying event remains poorly defined. Here we report that recombinant HSV-1 with a mutation in the γ(1)34.5 protein, a virulence factor, stimulates de...

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Detalles Bibliográficos
Autores principales: Ma, Yijie, Chen, Min, Jin, Huali, Prabhakar, Bellur S., Valyi-Nagy, Tibor, He, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288694/
https://www.ncbi.nlm.nih.gov/pubmed/28150813
http://dx.doi.org/10.1038/srep41461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288694/
https://www.ncbi.nlm.nih.gov/pubmed/28150813
http://dx.doi.org/10.1038/srep41461

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