Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

Nitric oxide synthase 2, inducible (Nos2) expression is necessary for the microbicidal activity of macrophages. However, NOS2 over-activation causes multiple inflammatory disorders, suggesting a tight gene regulation is necessary. Using cytosolic flagellin as a model for inflammasome-dependent NOS2...

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Detalles Bibliográficos
Autores principales: Buzzo, Carina de Lima, Medina, Tiago, Branco, Laura M., Lage, Silvia L., Ferreira, Luís Carlos de Souza, Amarante-Mendes, Gustavo P., Hottiger, Michael O., De Carvalho, Daniel D., Bortoluci, Karina R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288713/
https://www.ncbi.nlm.nih.gov/pubmed/28150715
http://dx.doi.org/10.1038/srep41686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288713/
https://www.ncbi.nlm.nih.gov/pubmed/28150715
http://dx.doi.org/10.1038/srep41686

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