Characterization of Highly Efficient RNA‐Cleaving DNAzymes that Function at Acidic pH with No Divalent Metal‐Ion Cofactors

Here, we describe the characterization of new RNA‐cleaving DNAzymes that showed the highest catalytic efficiency at pH 4.0 to 4.5, and were completely inactive at pH values higher than 5.0. Importantly, these DNAzymes did not require any divalent metal ion cofactors for catalysis. This clearly sugge...

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Detalles Bibliográficos
Autores principales: Kasprowicz, Aleksandra, Stokowa‐Sołtys, Kamila, Jeżowska‐Bojczuk, Małgorzata, Wrzesiński, Jan, Ciesiołka, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288747/
https://www.ncbi.nlm.nih.gov/pubmed/28168150
http://dx.doi.org/10.1002/open.201600141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288747/
https://www.ncbi.nlm.nih.gov/pubmed/28168150
http://dx.doi.org/10.1002/open.201600141

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