Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer

Pancreatic cancer (PC) evades immune destruction by favoring the development of regulatory T cells (Tregs) that inhibit effector T cells. The transcription factor Ikaros is critical for lymphocyte development, especially T cells. We have previously shown that downregulation of Ikaros occurs as a res...

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Detalles Bibliográficos
Autores principales: Nelson, Nadine, Szekeres, Karoly, Iclozan, Cristina, Rivera, Ivannie Ortiz, McGill, Andrew, Johnson, Gbemisola, Nwogu, Onyekachi, Ghansah, Tomar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289423/
https://www.ncbi.nlm.nih.gov/pubmed/28152014
http://dx.doi.org/10.1371/journal.pone.0170197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289423/
https://www.ncbi.nlm.nih.gov/pubmed/28152014
http://dx.doi.org/10.1371/journal.pone.0170197

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