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Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies

Attempts to elicit antibodies with potent neutralizing activity against a broad range of human immunodeficiency virus (HIV) isolates have so far proven unsuccessful. Long-term delivery of monoclonal antibodies (mAbs) with such activity is a creative alternative that circumvents the need for an immun...

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Detalles Bibliográficos
Autores principales: Fuchs, Sebastian P, Desrosiers, Ronald C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289440/
https://www.ncbi.nlm.nih.gov/pubmed/28197421
http://dx.doi.org/10.1038/mtm.2016.68