Continuous treatment with FTS confers resistance to apoptosis and affects autophagy

High percentage of human cancers involves alteration or mutation in Ras proteins, including the most aggressive malignancies, such as lung, colon and pancreatic cancers. FTS (Salirasib) is a farnesylcysteine mimetic, which acts as a functional Ras inhibitor, and was shown to exert anti-tumorigenic e...

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Detalles Bibliográficos
Autores principales: Schmukler, Eran, Wolfson, Eya, Elazar, Zvulun, Kloog, Yoel, Pinkas-Kramarski, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289601/
https://www.ncbi.nlm.nih.gov/pubmed/28151959
http://dx.doi.org/10.1371/journal.pone.0171351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289601/
https://www.ncbi.nlm.nih.gov/pubmed/28151959
http://dx.doi.org/10.1371/journal.pone.0171351

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