Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV

Activity and selectivity assessment of new bi-aryl amide 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors, prepared in a modular manner via Suzuki cross-coupling, are described. Several compounds inhibiting 11β-HSD1 at nanomolar concentrations were identified. Compounds 2b, 3e, 7b and 12e we...

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Detalles Bibliográficos
Autores principales: Boudon, Stéphanie M., Vuorinen, Anna, Geotti-Bianchini, Piero, Wandeler, Eliane, Kratschmar, Denise V., Heidl, Marc, Campiche, Remo, Jackson, Eileen, Odermatt, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289826/
https://www.ncbi.nlm.nih.gov/pubmed/28152550
http://dx.doi.org/10.1371/journal.pone.0171079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289826/
https://www.ncbi.nlm.nih.gov/pubmed/28152550
http://dx.doi.org/10.1371/journal.pone.0171079

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