A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

The adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications. Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes. We find that A-FABP levels are increased in both white (WAT...

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Detalles Bibliográficos
Autores principales: Shu, Lingling, Hoo, Ruby L. C., Wu, Xiaoping, Pan, Yong, Lee, Ida P. C., Cheong, Lai Yee, Bornstein, Stefan R, Rong, Xianglu, Guo, Jiao, Xu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290165/
https://www.ncbi.nlm.nih.gov/pubmed/28128199
http://dx.doi.org/10.1038/ncomms14147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290165/
https://www.ncbi.nlm.nih.gov/pubmed/28128199
http://dx.doi.org/10.1038/ncomms14147

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