Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å resolution crystal structure of the human ELL2 C-terminal domain bound to its...

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Detalles Bibliográficos
Autores principales: Qi, Shiqian, Li, Zichong, Schulze-Gahmen, Ursula, Stjepanovic, Goran, Zhou, Qiang, Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290273/
https://www.ncbi.nlm.nih.gov/pubmed/28134250
http://dx.doi.org/10.1038/ncomms14076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290273/
https://www.ncbi.nlm.nih.gov/pubmed/28134250
http://dx.doi.org/10.1038/ncomms14076

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