A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin. Here we report a novel pathway for mitochondrial eli...

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Detalles Bibliográficos
Autores principales: Hammerling, Babette C., Najor, Rita H., Cortez, Melissa Q., Shires, Sarah E., Leon, Leonardo J., Gonzalez, Eileen R., Boassa, Daniela, Phan, Sébastien, Thor, Andrea, Jimenez, Rebecca E., Li, Hong, Kitsis, Richard N., Dorn II, Gerald W., Sadoshima, Junichi, Ellisman, Mark H., Gustafsson, Åsa B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290275/
https://www.ncbi.nlm.nih.gov/pubmed/28134239
http://dx.doi.org/10.1038/ncomms14050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290275/
https://www.ncbi.nlm.nih.gov/pubmed/28134239
http://dx.doi.org/10.1038/ncomms14050

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