Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs

Pancancer studies have identified many genes that are frequently somatically altered across multiple tumour types, suggesting that pathway-targeted therapies can be deployed across diverse cancers. However, the same ‘actionable mutation' impacts distinct context-specific gene regulatory program...

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Detalles Bibliográficos
Autores principales: Osmanbeyoglu, Hatice U., Toska, Eneda, Chan, Carmen, Baselga, José, Leslie, Christina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290314/
https://www.ncbi.nlm.nih.gov/pubmed/28139702
http://dx.doi.org/10.1038/ncomms14249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290314/
https://www.ncbi.nlm.nih.gov/pubmed/28139702
http://dx.doi.org/10.1038/ncomms14249

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