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Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs
Pancancer studies have identified many genes that are frequently somatically altered across multiple tumour types, suggesting that pathway-targeted therapies can be deployed across diverse cancers. However, the same ‘actionable mutation' impacts distinct context-specific gene regulatory program...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290314/ https://www.ncbi.nlm.nih.gov/pubmed/28139702 http://dx.doi.org/10.1038/ncomms14249 |