Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

Cyclic AMP (cAMP)-specific phosphodiesterase-4 (PDE4) enzymes underpin compartmentalised cAMP signalling by localising to distinct signalling complexes. PDE4 long isoforms can be phosphorylated by mitogen-activated protein kinase-activated protein kinase 2 (MK2), which attenuates activation of such...

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Detalles Bibliográficos
Autores principales: Houslay, Kirsty F., Christian, Frank, MacLeod, Ruth, Adams, David R., Houslay, Miles D., Baillie, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290487/
https://www.ncbi.nlm.nih.gov/pubmed/27993970
http://dx.doi.org/10.1042/BCJ20160849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290487/
https://www.ncbi.nlm.nih.gov/pubmed/27993970
http://dx.doi.org/10.1042/BCJ20160849

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