Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer

BACKGROUND: Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linked to poor outcomes in this disease. Here, we investigate the effects of the MUC...

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Detalles Bibliográficos
Autores principales: Ahmad, Rehan, Alam, Maroof, Hasegawa, Masanori, Uchida, Yasumitsu, Al-Obaid, Omar, Kharbanda, Surender, Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290603/
https://www.ncbi.nlm.nih.gov/pubmed/28153010
http://dx.doi.org/10.1186/s12943-017-0608-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290603/
https://www.ncbi.nlm.nih.gov/pubmed/28153010
http://dx.doi.org/10.1186/s12943-017-0608-9

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