Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methylation studies have highlighted an important role of dysregulated methylation signature in A...

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Autores principales: Li, Yan, Xu, Qingyu, Lv, Na, Wang, Lili, Zhao, Hongmei, Wang, Xiuli, Guo, Jing, Chen, Chongjian, Li, Yonghui, Yu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290606/
https://www.ncbi.nlm.nih.gov/pubmed/28153026
http://dx.doi.org/10.1186/s13045-017-0409-z
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author Li, Yan
Xu, Qingyu
Lv, Na
Wang, Lili
Zhao, Hongmei
Wang, Xiuli
Guo, Jing
Chen, Chongjian
Li, Yonghui
Yu, Li
author_facet Li, Yan
Xu, Qingyu
Lv, Na
Wang, Lili
Zhao, Hongmei
Wang, Xiuli
Guo, Jing
Chen, Chongjian
Li, Yonghui
Yu, Li
author_sort Li, Yan
collection PubMed
description Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methylation studies have highlighted an important role of dysregulated methylation signature in AML from biological and clinical standpoint. In this review, we will outline the recent advances in the methylome study of AML and overview the impacts of DNA methylation on AML diagnosis, treatment, and prognosis.
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spelling pubmed-52906062017-02-09 Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia Li, Yan Xu, Qingyu Lv, Na Wang, Lili Zhao, Hongmei Wang, Xiuli Guo, Jing Chen, Chongjian Li, Yonghui Yu, Li J Hematol Oncol Review Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methylation studies have highlighted an important role of dysregulated methylation signature in AML from biological and clinical standpoint. In this review, we will outline the recent advances in the methylome study of AML and overview the impacts of DNA methylation on AML diagnosis, treatment, and prognosis. BioMed Central 2017-02-02 /pmc/articles/PMC5290606/ /pubmed/28153026 http://dx.doi.org/10.1186/s13045-017-0409-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Yan
Xu, Qingyu
Lv, Na
Wang, Lili
Zhao, Hongmei
Wang, Xiuli
Guo, Jing
Chen, Chongjian
Li, Yonghui
Yu, Li
Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia
title Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia
title_full Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia
title_fullStr Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia
title_full_unstemmed Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia
title_short Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia
title_sort clinical implications of genome-wide dna methylation studies in acute myeloid leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290606/
https://www.ncbi.nlm.nih.gov/pubmed/28153026
http://dx.doi.org/10.1186/s13045-017-0409-z
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