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An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs

BACKGROUND: Population based epigenetic association studies of disease and exposures are becoming more common with the availability of economical genome-wide technologies for interrogation of the methylome, such as the Illumina 450K Human Methylation Array (450K). Often, the expected small number of...

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Detalles Bibliográficos
Autores principales: Edgar, Rachel D., Jones, Meaghan J., Robinson, Wendy P., Kobor, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290610/
https://www.ncbi.nlm.nih.gov/pubmed/28184257
http://dx.doi.org/10.1186/s13148-017-0320-z