IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking

BACKGROUND: Pro-inflammatory cytokines accumulate in the brain with age and Alzheimer’s disease and can impair neuron health and cognitive function. Brain-derived neurotrophic factor (BDNF) is a key neurotrophin that supports neuron health, function, and synaptic plasticity. The pro-inflammatory cyt...

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Detalles Bibliográficos
Autores principales: Carlos, Anthony J., Tong, Liqi, Prieto, G. Aleph, Cotman, Carl W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290618/
https://www.ncbi.nlm.nih.gov/pubmed/28153028
http://dx.doi.org/10.1186/s12974-017-0803-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290618/
https://www.ncbi.nlm.nih.gov/pubmed/28153028
http://dx.doi.org/10.1186/s12974-017-0803-z

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