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IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking
BACKGROUND: Pro-inflammatory cytokines accumulate in the brain with age and Alzheimer’s disease and can impair neuron health and cognitive function. Brain-derived neurotrophic factor (BDNF) is a key neurotrophin that supports neuron health, function, and synaptic plasticity. The pro-inflammatory cyt...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290618/ https://www.ncbi.nlm.nih.gov/pubmed/28153028 http://dx.doi.org/10.1186/s12974-017-0803-z |