Synergetic effects of DNA methylation and histone modification during mouse induced pluripotent stem cell generation

DNA methylation and histone methylation (H3K27me3) have been reported as major barriers to induced pluripotent stem cell (iPSC) generation using four core transcription factors (Oct4, Sox2, Klf4, and c-Myc, termed OSKM). Here, to illustrate the possibility of deriving iPSCs via demethylation, as wel...

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Detalles Bibliográficos
Autores principales: Wang, Guiying, Weng, Rong, Lan, Yuanyuan, Guo, Xudong, Liu, Qidong, Liu, Xiaoqin, Lu, Chenqi, Kang, Jiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290738/
https://www.ncbi.nlm.nih.gov/pubmed/28155862
http://dx.doi.org/10.1038/srep39527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290738/
https://www.ncbi.nlm.nih.gov/pubmed/28155862
http://dx.doi.org/10.1038/srep39527

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