The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin α(IIb)β(3) Outside-in Signaling

The class I PI3K family of lipid kinases plays an important role in integrin α(IIb)β(3) function, thereby supporting thrombus growth and consolidation. Here, we identify Ras/Rap1GAP Rasa3 (GAP1(IP4BP)) as a major phosphatidylinositol 3,4,5-trisphosphate-binding protein in human platelets and a key r...

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Detalles Bibliográficos
Autores principales: Battram, Anthony M., Durrant, Tom N., Agbani, Ejaife O., Heesom, Kate J., Paul, David S., Piatt, Raymond, Poole, Alastair W., Cullen, Peter J., Bergmeier, Wolfgang, Moore, Samantha F., Hers, Ingeborg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290945/
https://www.ncbi.nlm.nih.gov/pubmed/27903653
http://dx.doi.org/10.1074/jbc.M116.746867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290945/
https://www.ncbi.nlm.nih.gov/pubmed/27903653
http://dx.doi.org/10.1074/jbc.M116.746867

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