Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface

Cystic fibrosis transmembrane conductance regulator (CFTR) is a multidomain membrane protein that functions as a phosphorylation-regulated anion channel. The interface between its two cytosolic nucleotide binding domains and coupling helices conferred by intracellular loops extending from the channe...

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Detalles Bibliográficos
Autores principales: Chin, Stephanie, Yang, Donghe, Miles, Andrew J., Eckford, Paul D. W., Molinski, Steven, Wallace, B. A., Bear, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290968/
https://www.ncbi.nlm.nih.gov/pubmed/28003367
http://dx.doi.org/10.1074/jbc.M116.762633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290968/
https://www.ncbi.nlm.nih.gov/pubmed/28003367
http://dx.doi.org/10.1074/jbc.M116.762633

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