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Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology

Membrane proteins frequently assemble into higher order homo- or hetero-oligomers within their natural lipid environment. This complex formation can modulate their folding, activity as well as substrate selectivity. Non-disruptive methods avoiding critical steps, such as membrane disintegration, tra...

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Detalles Bibliográficos
Autores principales: Henrich, Erik, Peetz, Oliver, Hein, Christopher, Laguerre, Aisha, Hoffmann, Beate, Hoffmann, Jan, Dötsch, Volker, Bernhard, Frank, Morgner, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291076/
https://www.ncbi.nlm.nih.gov/pubmed/28067619
http://dx.doi.org/10.7554/eLife.20954