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Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway
The polymeric structure of secretory IgM allows efficient antigen binding and complement fixation. The available structural models place the N-glycans bound to asparagines 402 and 563 of Ig-μ chains within a densely packed core of native IgM. These glycans are found in the high mannose state also in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291101/ https://www.ncbi.nlm.nih.gov/pubmed/28157181 http://dx.doi.org/10.1038/srep41815 |