Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway

The polymeric structure of secretory IgM allows efficient antigen binding and complement fixation. The available structural models place the N-glycans bound to asparagines 402 and 563 of Ig-μ chains within a densely packed core of native IgM. These glycans are found in the high mannose state also in...

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Detalles Bibliográficos
Autores principales: Giannone, Chiara, Fagioli, Claudio, Valetti, Caterina, Sitia, Roberto, Anelli, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291101/
https://www.ncbi.nlm.nih.gov/pubmed/28157181
http://dx.doi.org/10.1038/srep41815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291101/
https://www.ncbi.nlm.nih.gov/pubmed/28157181
http://dx.doi.org/10.1038/srep41815

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