Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites

Excessive myocardial collagen deposition and cross-linking (CCL), a process regulated by lysyl oxidase (LOX), determines left ventricular (LV) stiffness and dysfunction. The angiotensin II antagonist losartan, metabolized to the EXP3179 and EXP3174 metabolites, reduces myocardial fibrosis and LV sti...

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Detalles Bibliográficos
Autores principales: Miguel-Carrasco, José Luis, Beaumont, Javier, San José, Gorka, Moreno, María U., López, Begoña, González, Arantxa, Zalba, Guillermo, Díez, Javier, Fortuño, Ana, Ravassa, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291109/
https://www.ncbi.nlm.nih.gov/pubmed/28157237
http://dx.doi.org/10.1038/srep41865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291109/
https://www.ncbi.nlm.nih.gov/pubmed/28157237
http://dx.doi.org/10.1038/srep41865

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