Structural and functional analyses of the archaeal tRNA m(2)G/m(2)(2)G10 methyltransferase aTrm11 provide mechanistic insights into site specificity of a tRNA methyltransferase that contains common RNA-binding modules

N(2)-methylguanosine is one of the most universal modified nucleosides required for proper function in transfer RNA (tRNA) molecules. In archaeal tRNA species, a specific S-adenosyl-L-methionine (SAM)-dependent tRNA methyltransferase (MTase), aTrm11, catalyzes formation of N(2)-methylguanosine and N...

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Detalles Bibliográficos
Autores principales: Hirata, Akira, Nishiyama, Seiji, Tamura, Toshihiro, Yamauchi, Ayano, Hori, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291279/
https://www.ncbi.nlm.nih.gov/pubmed/27325738
http://dx.doi.org/10.1093/nar/gkw561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291279/
https://www.ncbi.nlm.nih.gov/pubmed/27325738
http://dx.doi.org/10.1093/nar/gkw561

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