DNMT 1 maintains hypermethylation of CAG promoter specific region and prevents expression of exogenous gene in fat-1 transgenic sheep

Methylation is an important issue in gene expression regulation and also in the fields of genetics and reproduction. In this study, we created fat-1 transgenic sheep, investigated the fine-mapping and the modulatory mechanisms of promoter methylation. Sheep fetal fibroblasts were transfected by pCAG...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Chunrong, Shang, Xueying, Cheng, Lei, Yang, Lei, Liu, Xuefei, Bai, Chunling, Wei, Zhuying, Hua, Jinlian, Li, Guangpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291418/
https://www.ncbi.nlm.nih.gov/pubmed/28158319
http://dx.doi.org/10.1371/journal.pone.0171442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291418/
https://www.ncbi.nlm.nih.gov/pubmed/28158319
http://dx.doi.org/10.1371/journal.pone.0171442

Ejemplares similares