Cargando…

DNMT 1 maintains hypermethylation of CAG promoter specific region and prevents expression of exogenous gene in fat-1 transgenic sheep

Methylation is an important issue in gene expression regulation and also in the fields of genetics and reproduction. In this study, we created fat-1 transgenic sheep, investigated the fine-mapping and the modulatory mechanisms of promoter methylation. Sheep fetal fibroblasts were transfected by pCAG...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Chunrong, Shang, Xueying, Cheng, Lei, Yang, Lei, Liu, Xuefei, Bai, Chunling, Wei, Zhuying, Hua, Jinlian, Li, Guangpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291418/ https://www.ncbi.nlm.nih.gov/pubmed/28158319 http://dx.doi.org/10.1371/journal.pone.0171442

Ejemplares similares

Comparative Transcriptome Analysis Provides Insights into the Polyunsaturated Fatty Acid Synthesis Regulation of Fat-1 Transgenic Sheep
por: Luo, Rongsong, et al.
Publicado: (2020)

N-3 Polyunsaturated Fatty Acid Dehydrogenase Fat-1 Regulates Mitochondrial Energy Metabolism by Altering DNA Methylation in Isolated Cells of Transgenic Cattle
por: Wang, Xueqiao, et al.
Publicado: (2022)

Microarray Analysis of the Gene Expression Profile and Lipid Metabolism in Fat-1 Transgenic Cattle
por: Liu, Xinfeng, et al.
Publicado: (2015)

DNMT1-maintained hypermethylation of Krüppel-like factor 5 involves in the progression of clear cell renal cell carcinoma
por: Fu, Rong-Jie, et al.
Publicado: (2017)

Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
por: Wei, Zhuying, et al.
Publicado: (2018)

Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle
por: Gu, Mingjuan, et al.
Publicado: (2022)

Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development
por: Zhang, Bao-gui, et al.
Publicado: (2016)

Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas
por: Gömöri, Éva, et al.
Publicado: (2012)

MSTN Mutant Promotes Myogenic Differentiation by Increasing Demethylase TET1 Expression via the SMAD2/SMAD3 Pathway
por: Gao, Li, et al.
Publicado: (2020)

Histone Demethylase UTX is an Essential Factor for Zygotic Genome Activation and Regulates Zscan4 Expression in Mouse Embryos
por: Bai, Lige, et al.
Publicado: (2019)

Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle
por: Wu, Di, et al.
Publicado: (2022)

The CAG promoter maintains high‐level transgene expression in HEK293 cells
por: Dou, Yuanyuan, et al.
Publicado: (2020)

Myostatin Deficiency Enhances Antioxidant Capacity of Bovine Muscle via the SMAD-AMPK-G6PD Pathway
por: Zhu, Lin, et al.
Publicado: (2022)

Myostatin Knockout Limits Exercise-Induced Reduction in Bovine Erythrocyte Oxidative Stress by Enhancing the Efficiency of the Pentose Phosphate Pathway
por: Zhu, Lin, et al.
Publicado: (2022)

DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
por: Kerdivel, Gwenneg, et al.
Publicado: (2023)

Low Expression of Mitofusin 1 Gene Leads to Mitochondrial Dysfunction and Embryonic Genome Activation Failure in Ovine-Bovine Inter-Species Cloned Embryos
por: Wu, Shanshan, et al.
Publicado: (2022)

Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis
por: Yuan, Ziqiang, et al.
Publicado: (2016)

Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1
por: Wiseman, Ashley K., et al.
Publicado: (2022)

Exploring timing activation of functional pathway based on differential co-expression analysis in preimplantation embryogenesis
por: Zuo, Yongchun, et al.
Publicado: (2016)

Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle
por: Wang, Xueqiao, et al.
Publicado: (2022)

Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion
por: Wu, Rile, et al.
Publicado: (2019)

Downregulation of CAMK2N1 due to DNA Hypermethylation Mediated by DNMT1 that Promotes the Progression of Prostate Cancer
por: Peng, Wei, et al.
Publicado: (2023)

DNA methylation subpatterns at distinct regulatory regions in human early embryos
por: Luo, Rongsong, et al.
Publicado: (2018)

Correction to ‘DNA methylation subpatterns at distinct regulatory regions in human early embryos’
por: Luo, Rongsong, et al.
Publicado: (2018)

Growth Traits and Sperm Proteomics Analyses of Myostatin Gene-Edited Chinese Yellow Cattle
por: Zhao, Yuefang, et al.
Publicado: (2022)

DNMT1 Maintains Progenitor Function in Self-Renewing Somatic Tissue
por: Sen, George L., et al.
Publicado: (2010)

Generation of Fad2 and Fad3 transgenic mice that produce n-6 and n-3 polyunsaturated fatty acids
por: Song, Lishuang, et al.
Publicado: (2019)

Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice
por: Sasaki, Keisuke, et al.
Publicado: (2019)

Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa
por: Takano, Hikaru, et al.
Publicado: (2020)

FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
por: Lin, Zhuoying, et al.
Publicado: (2021)

LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1
por: Yu, Xiao, et al.
Publicado: (2021)

Effects of Different Generations and Sex on Physiological, Biochemical, and Growth Parameters of Crossbred Beef Cattle by Myostatin Gene-Edited Luxi Bulls and Simmental Cows
por: Hai, Chao, et al.
Publicado: (2023)

iDPF-PseRAAAC: A Web-Server for Identifying the Defensin Peptide Family and Subfamily Using Pseudo Reduced Amino Acid Alphabet Composition
por: Zuo, Yongchun, et al.
Publicado: (2015)

Comparison of Microbial Community and Metabolites in Four Stomach Compartments of Myostatin-Gene-Edited and Non-edited Cattle
por: Zhou, Xinyu, et al.
Publicado: (2022)

Coexpression analysis identifies nuclear reprogramming barriers of somatic cell nuclear transfer embryos
por: Zuo, Yongchun, et al.
Publicado: (2017)

Long Tract of Untranslated CAG Repeats Is Deleterious in Transgenic Mice
por: Hsu, Ren-Jun, et al.
Publicado: (2011)

ERα propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells
por: Si, Xinxin, et al.
Publicado: (2016)

Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas
por: Ma, Hou-Shi, et al.
Publicado: (2018)

Exogenous Melatonin Directly and Indirectly Influences Sheep Oocytes
por: Chen, Yang, et al.
Publicado: (2022)

Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway
por: Soberanes, Saul, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kelf199gh8f8h12sogmath71g1